Who we are

Pictured: Dr. Tim Murphy, Cluster Lead

The fundamental mission of Neuroscience is to take molecular and cellular information, together with mapping pathways in the brain, to understand behavior.

A central focus of this research at UBC is the study of brain connections and their dynamic changes during development, learning and how they are altered in disease. Mapping the brain’s vital wiring diagram called the “connectome” represents the structural and functional circuits between brain cells that underlies all brain function. Virtually all aspects of brain imaging from animal synapse work to human PET and MRI reflect activity within these connections.

The main goals of the Dynamic Brain Circuits and Connections in Health and Disease cluster are:

  • to understand brain circuit connections and their changes in diseases and the at-risk brain;
  • to empirically model brain diseases to establish mechanistic insights; 
  • to define the molecular genetic etiology of brain disorders;
  • to translate new knowledge towards treating brain disorders with novel circuit-based therapeutic approaches​;

Dynamic Brain Circuits-based research is a logical step towards developing the first circuit-based treatments for brain disease. The next phase of the cluster will facilitate training and collaboration to develop new models of brain connectivity disorders and analyze multiple streams of imaging, genetic, and biochemical data.

Investigators in this research cluster